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15th International Conference on Genetic Disorders and Gene Therapy, will be organized around the theme “The genetic researches to elucidate the susceptibility and severity of the pandemic: Covid-19”
Genetics 2021 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Genetics 2021
Submit your abstract to any of the mentioned tracks.
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Genetics is the inheritance analysis. Heredity is a biological process in which the parent transmits those genes to their children or offspring. Each child inherits genes from both their biological parents and, in exchange, expresses specific traits. Some of these characteristics may be physical, e.g. hair and eye colour, skin colour, etc. On the other hand, certain genes may also carry the risk of certain diseases and disorders that can spread to their offspring from parents.
- Track 1-1Cardiovascular Disorder
- Track 1-2Epigenomics
- Track 1-3Behavioural Genetics.
- Track 1-4Classical Genetics.
- Track 1-5Developmental Genetics.
- Track 1-6Conservation Genetics.
- Track 1-7Ecological Genetics.
- Track 1-8Genetic Engineering. Metagenics.
Gene Therapy basically involves the introduction or alteration of genetic material within a cell or organism with an intention of curing the disease. Both cell therapy and gene therapy are overlapping fields of biomedical research with the goals of repairing the direct cause of Genetic diseases in DNA or cellular population respectively, the discovery of recombinant DNA technology in the 1970s provided tools to efficiently develop gene therapy. Scientists use these techniques to readily manipulate viral genomes, isolate genes and identify mutations involved in human disease, characterize and regulate gene expressions, and engineer various viral and non-viral vectors. Various long-term treatments for anaemia, haemophilia, cystic fibrosis, muscular dystrophy, Gauscher’s disease, lysosomal storage diseases, cardiovascular diseases, diabetes and diseases of bones and joints are resolved through successful gene therapy
- Track 2-1Gene therapy products
- Track 2-2Process of gene therapy
- Track 2-3Different vectors for gene therapy
- Track 2-4Gene therapy for Diabetes
- Track 2-5Gene therapy for age related macular degeneration
Nano therapy is a Nano medicine branch that involves using nanoparticles to deliver a drug to a specific target body position to treat the disease through a process called targeting. This technique has become more popular compared to conventional approaches because it provides high precision when it comes to the delivery of therapeutic formulations. There is no targeting for conventional chemotherapy, which means that the drug is merely carried by the circulatory system until it enters and works on the affected part of the body.
- Track 3-1Passive Targeting
- Track 3-2Active Targeting
- Track 3-3Passive Targeting
- Track 3-4Active Targeting
Customary methods for quality treatment fuse transfection. It twisted up evidently inefficient and confined fundamentally in light of transport of value into at present duplicating cells in-vitro. Quality treatment utilizes the transport of DNA into cells by techniques for vectors, for instance, natural nanoparticles or viral vectors and non-viral methodologies. The Several sorts of diseases vectors used as a piece of value treatment are retrovirus, adenovirus, adeno-related contamination and herpes simplex contamination. While other recombinant viral vector structures have been delivered, retroviral vectors remain the most surely understood vector system for quality treatment traditions and most prominent application in view of their undeniable significance as the essential vectors made for powerful quality treatment application and the soonest phases of the field of value treatment.
- Track 4-1Non-viral methods
- Track 4-2Hybrid method
- Track 4-3Viruses
- Track 4-4Chemical methods to enhance delivery
Fortunately, with no medical problems or birth defects, most children are born healthy. Nevertheless, some children are born with differences in body structure, brain development, or body chemistry that may lead to problems with health, development, school performance, and/or social interaction. Pediatric geneticists were trained to identify the causes and history of these diseases. They may suggest tests and treatments that may help you understand and take care of the condition of your child. Pediatric geneticists can also help families understand whether certain disorders are inherited (from genes) and provide screening to family members who may be at risk of having children with similar problems.
- Track 5-1Birth defects
- Track 5-2Down syndrome
- Track 5-3Fetal alcohol syndrome
- Track 5-4Inborn errors of metabolism
- Track 5-5Familial or hereditary problems
- Track 5-6Short or tall stature
Genes are heredity form squares. They're transferred from one parent to another. We carry the DNA, the instructions to produce proteins. The proteins do the vast majority of cell function. We transfer particles from one place to the next, form structures, isolate toxins, and perform various other support tasks. At times there is a change, a value improvement, or gene modification. The conversion changes the criteria of the quality to make a protein, so the protein does not function properly or is completely missing.
- Track 6-1Multifactorial disorder
- Track 6-2Chromosomal disorder
Genetics in Health and Disease in which therapy utilizes genetics, imaging and biological indicators to understand predisposition to disease, what constitutes health during childhood and throughout the life course. Gene and Protein Function are used to develop tools, skills and resources to elucidate gene function and to inform development of new therapies using state-of the-art technologies. Personalised Medicine and Patient benefit is considered to ensure basic science discoveries of disease mechanisms and patient’s genomes are used to produce best effect to improve patients’ lives which include better diagnostics, identification of biomarkers and targeting of therapies.
- Track 7-1Gene Therapy and Genetic Engineering
- Track 7-2Somatic Gene Therapy
- Track 7-3Germ Line Gene Therapy
- Track 7-4Cell Cancer Immunotherapy
- Track 7-5Somatic Cell Nuclear Transfer (SCNT)
Gene Therapy is used to treat inherited Muscular disorder, cardiovascular disorder, HIV, cancer etc. In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or as a way for the donor's immune system to provoke immunity against some types of cancer and blood-related diseases, such as leukaemia. Cellular Therapy is internationally recognized for its novel approaches in treating blood related disorders like leukaemia, lymphoma, myeloma, and other life-threatening diseases. The stem cell transplantation of hematopoietic stem cells (HSCT) in which the allogeneic hematopoietic stem cells are harvested from healthy donors of same species and autologous stem cell from the patient itself. Both therapies use high dosage cytotoxic medication in order to induce higher remission rates against malignant diseases. Autologous HSCT preferably used in relapsed malignant high-grade lymphoma and Allogeneic HSCT preferred for therapeutic effect against acute leukaemia with unfavourable prognosis in a high percentage of patients. The Recent developments based on the expansion of the donor pool for allogeneic stem cells in order to reduce dosage as well as chemotherapeutic toxicity of allogeneic transplantation with sustainable anti-leukaemia efficacy
- Track 8-1Neurological Disorder
- Track 8-2Blindness Vision Impairment
- Track 8-3Wound Healing
- Track 8-4Cancer
- Track 8-5HIV
Genome editing with engineered nucleases (GEEN) is emergent type of Genetic Engineering. GEEN is the technology in which DNA is inserted, deleted or replaced in the genome. The emergence of highly versatile genome-editing technologies has provided investigators with the ability to rapidly and economically introduce sequence-specific modifications into the genomes of a broad spectrum of cell types and organisms. It also promotes various changes in sub cellular level. Genome Editing itself also holds tremendous potential for treating the underlying various idiopathic genetic causes of certain diseases. The core technologies now most commonly used techniques to facilitate genome editing are clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs), and homing endonucleases or mega nucleases.
- Track 9-1Detecting conditions
- Track 9-2Market and Future Prospects of Gene Therapy
- Track 9-3Paediatrics’ and Genetics
- Track 9-4Cell therapy: clinical trials
- Track 9-5Stem cell and cellular therapies
- Track 9-6Prenatal genetics
- Track 9-7Pediatric genetics
- Track 9-8Neurogenetics
- Track 9-9Hereditary cancer genetics
- Track 9-10Cardiovascular genetics
- Track 9-11ART/Infertility genetics
- Track 9-12ART/Infertility genetics
- Track 9-13Adult genetics
- Track 9-14Gene Editing and CRISPR Based Technologies
Functionality of biomaterials for these forms is depends upon the chemical reaction such as localized or systemic response at the surface tethered moieties or encapsulated therapeutic factors such as drugs, genes, cells, growth factors, hormones and other active agents to specific target sites. The application of functional biomaterials is rehabilitation, reconstruction, regeneration, repair, ophthalmic applications and act as therapeutic solutions. It has the property of biocompatibility and produce inertness response to the tissue. The biomaterial-mediated gene therapy aim to use polymeric gene therapy systems to halt the progression of neuron loss through neuro-protective routes and it combine stem cell therapy and biomaterial delivery system in order to enhance regeneration or repair after ischemic injury.
- Track 10-1Cardiac Progenitor Cells
- Track 10-2Bio fabrication and Bone Tissue
- Track 10-3Mitochondrial genetics
- Track 10-4Diagnostic evaluation
- Track 10-5Molecular genetics
- Track 10-6Cytogenetic
- Track 10-7Metabolic/biochemical genetics
- Track 10-8Gene Therapy Challenges
- Track 10-9Gene Therapy Techniques
- Track 10-10Mesenchymal Cells
- Track 10-11Regeneration Manufacturing Challenges for Regenerative Medicine
Clinical Trials of Cell and Gene Therapy products often varying from the clinical trials design for other types of pharmaceutical products. This differences in trial design are necessitated by the distinctive features of these products. The clinical trials also reflect previous clinical experience and evidence of medicine. Early experiences with Cell and Gene Therapy products indicate that some CGT products may pose substantial risks to subjects due to effect at cellular and genetic level. The design of early-phase clinical trials of Cell and Gene Therapy products often involves the following consideration of clinical safety issues, preclinical issues, and chemistry, manufacturing and controls (CMC) issues that are encountered
- Track 11-1Gene Therapy Techniques
- Track 11-2Gene Therapy Challenges
Fertilization and Embryogenesis is the process of Fusion of sperm and ovum to form Zygote. Fertilization usually takes place in oviduct. Ovum is in secondary oocyte stage during fertilization. Secondary oocyte is surrounded by two layer-zona pellucida and zona reticulate. Sperm move toward the secondary oocyte and bind to the receptor on zona pellucida. After sperm enter the oocyte, the zona pellucida become fertilization membrane preventing other sperm to enter. It is the entry of sperm that stimulate second meiotic division of Oocyte . Acrosome of sperm release proteolytic enzyme (Hyaluronidase) that digests the egg wall and then the pro-nucleuses fuse form zygote (2n). Zygote undergoes repeated cell division called cleavage. Cleavage starts as the zygote moves down from oviduct to uterus 3-5 days after fertilization, zygote develop into ball like structure of cell with central cavity; blastocyst (Blastula stage).Outer cell of blastocyst is known as trophoblastic cell while inner cell is known as embryonic cell. Trophoblastic cell secrete HCG (human chorionic gonadotropin) hormone; similar in function as LH. It Prevent degredation of corpus luteum, therefore corpus luteum continue to secrete progesterone and oestrogen, which help continuous growth of endometrium wall causing menstruation cycle to stop.
- Track 12-1Predicting the intracellular localization of the recombinant protein
- Track 12-2Induced Pluripotent Stem Cells
- Track 12-3Adult Stem Cells
- Track 12-4Tissue Stem Cells
- Track 12-5Embryonic Stem Cells
- Track 12-6Application of Stem Cell
- Track 12-7Epigenetics and Cancer Stem Cells
Malignancy cells Integrated from Healthy cells from multiple points of view that Access them to become out of administration and move toward becoming Metastasis. One imperative refinement is that growth cells territory unit less specific than conventional cells. That is, while customary cells develop into frightfully particular cell assortments with particular capacities, disease cells don't. This is regularly one reason that, as opposed to customary cells, growth cells still separation no end. Incidentally, willcer cells can initiate close conventional cells to make veins that furnish tumors with O and supplements that they need to develop. These veins conjointly take away waste item from tumours. Biomarkers region unit particles that demonstrate customary or unusual technique occurring in your body and will be an indication of partner degree fundamental condition or sickness. Various sorts of atoms acknowledge deoxyribonucleic corrosive (qualities), proteins or hormones, will work biomarkers, since every one of them show one thing in regards to your wellbeing. Biomarkers could likewise be made by the disease tissue itself or by elective cells inside the body because of malignancy.
- Track 13-1Genomics biomarkers
- Track 13-2Immuno-Oncology Biomarkers
- Track 13-3Molecular Biomarkers
- Track 13-4Biomarkers in Clinical Research and Development
The genomes consist of the total amount of genetic material required to encode human life's blueprint. For normal cell division, normal function of our tissues and organs, healthy ageing, and the prevention of diseases such as cancer, successful preservation of genome integrity and stability are important. Processes that regulate the preservation of genome integrity include sensing, signalling and repairing DNA damage, chromatin and chromosome DNA damage storage, cell cycle checkpoint regulation, and cell death control. Many of the fundamental aspects of the integrity of the genome — such as how cells feel and handle DNA damage — are still not well understood.
Cancer is a genetic problem where normal cell enhancement regulation is lost. Now, cancer biology is one of the fastest-growing cell differentiating abilities. At the nuclear level, a mutation(s) of DNA causes cancer, resulting in the development of twisted cells. The increasing dimension of these changes is guarded and occurs in external cells. In any case, the germ line is secured by a couple of individuals. The mutation(s) occurs in two cell characteristics classes on cogeneses and the characteristics of the tumour silencer. Tumour silencer characteristics monitor cell division and extension camouflage under standard conditions. Changes in these characteristics lead to unregulated cell replication which results in tumours with odd cell cycles and growth of tumours. The features of the tumour silencer contribute to the disease by inactivating limit Biogenesis Cancer cytogenetic
Human genetics, is study for Analysis of the parent's succession of characteristics. In human heritage as no fundamental way differs from that in other organisms. Human heredity research occupies a key genetic role. Much of this fascination derives from a deep desire to know who and why human beings are as they are. In a more practical way, Understanding human inheritance is critical in the prediction, diagnosis and treatment of genetic diseases. The quest to establish human health's genetic basis has given rise to the medical genetics industry. Medicine has generally given emphasis and purpose to human genetics, so it is often considered interchangeable with the terms of clinical genetics and human genetics.