16^th International Conference on Genetic Disorders and Gene Therapy November 09-10, 2022 Rome, Italy

Rome (Italian and Latin: Roma [ˈroːma] (listen)) is the capital city of Italy. It is also the capital of the Lazio region, the centre of the Metropolitan City of Rome, and a special commune named Commune di Roma Capital. With 2,860,009 residents in 1,285 km2 (496.1 sq. mi),[1] Rome is the country's most populated commune and the third most populous city in the European Union by population within city limits. The Metropolitan City of Rome, with a population of 4,355,725 residents, is the most populous metropolitan city in Italy. Its metropolitan area is the third-most populous within Italy. Rome is located in the central-western portion of the Italian Peninsula, within Lazio (Latium), along the shores of the Tiber. Vatican City (the smallest country in the world) is an independent country inside the city boundaries of Rome, the only existing example of a country within a city. Rome is often referred to as the City of Seven Hills due to its geographic location, and also as the "Eternal City". Rome is generally considered to be the "cradle of Western civilization and Christian culture", and the centre of the Catholic Church.

Rome's history spans 28 centuries. While Roman mythology dates the founding of Rome at around 753 BC, the site has been inhabited for much longer, making it a major human settlement for almost three millennia and one of the oldest continuously occupied cities in Europe.[9] The city's early population originated from a mix of Latin’s, Etruscans, and Sabine’s. Eventually, the city successively became the capital of the Roman Kingdom, the Roman Republic and the Roman Empire, and is regarded by many as the first-ever Imperial city and metropolis.[10] It was first called The Eternal City (Latin: Urbs Aeterna; Italian: La Città Eternal) by the Roman poet Tibullus in the 1st century BC, and the expression was also taken up by Ovid, Virgil, and Livy. Rome is also called "Caput Mundi" (Capital of the World). After the fall of the Empire in the west, which marked the beginning of the middle Ages, Rome slowly fell under the political control of the Papacy, and in the 8th century, it became the capital of the Papal States, which lasted until 1870. Beginning with the Renaissance, almost all popes since Nicholas V (1447–1455) pursued a coherent architectural and urban programme over four hundred years, aimed at making the city the artistic and cultural centre of the world.[13] In this way, Rome became first one of the major centres of the Renaissance, and then the birthplace of both the Baroque style and Neoclassicism. Famous artists, painters, sculptors, and architects made Rome the centre of their activity, creating masterpieces throughout the city. In 1871, Rome became the capital of the Kingdom of Italy, which, in 1946, became the Italian Republic.